Page 91 - 2015-16

CSIR-IHBT Annual Report 2015-16

Yogendra S. Padwad, Scientist

yogendra@ihbt.res.in
Research Area: In vitro and in vivo pharmacology

Anticancer and immunomodulatory potentials of Tinospora cordifolia: The plant is widely
used in various traditional medicinal systems including "Ayurveda" for the treatment of jaundice,
rheumatism, urinary disorder, skin diseases, diabetes and anaemia. The phytoconstituents present
in the plant belongs to different class of compounds such as alkaloids, diterpenoids lactones,
glycosides, steroids, phenol, aliphatic compounds and polysaccharides. With this background,
present study addressed the isolation, structure elucidation, quantification and evaluation of
anticancer and immunomodulatory potential of secondary metabolites.
The anti-cancer activities of different extracts, fractions and isolated compounds were evaluated
on four different human cancer cell lines, KB (human oral squamous carcinoma), CHOK-
1(hamster ovary), HT-29 (human colon cancer) and SiHa (human cervical cancer).
Immunomodulatory potential was determined on murine primary splenocytes (Fig.1).
All extracts and fractions
were active against KB and
CHOK-1 cells, whereas,
palmatine was active
against KB and HT-29;
tinocordiside against KB
and CHOK-1 and
yangambin against KB
c e l l s . H o w e v e r, N - Fig.1. Phytochemical proling, in vitro anticancer and
formylannonain and 11- immunomodulatory activities of Tinospora cordifolia.
hydroxymustakone showed
immunomodulatory
activity.
Publications:

· Koundal R, Kumar D, Walia M, Kumar A, Thakur S, Gopichand, Padwad YS and Agnihotri
VK (2016) Chemical and in vitro cytotoxicity evaluation of essential oil from Eucalyptus
citriodora fruits growing in the Northwestern Himalaya, India. Flavour Fragrance
Journal, 31:158–162.

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